Friday, 8 June 2018

Pharmacology Made Simple : Typhoid Vaccine

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Typhoid Vaccine

Also known as Vi Capsular Polysaccharide Typhoid Vaccine is a colourless and transparent injection in liquid form containing Vi capsular polysaccharide .

Composition is 0.5 ml that contains purified Vi capsular polysaccharide of Salmonella Typhu 25 mcg.

Indications:
Prevention of Typhoid fever in adults and children over 2 years of age.

Dosage :
 A single intramuscular injection of  Typbar 0.5 ml for adults and children over 2 years of age.

The protection lasts for upto  3 years.


Revaccination is needed once every 3 years to maintain protection.

Precautions:
Immunisation should be postponed in febrile subjects or in persons with acute infection.


Contraindications:

1. Hypersensitivity to any constituent of vaccine.


2. Pregnancy and lactation:
The risk during pregnancy is currently not exactly known.

Adverse Effects:

Mild pain at injection site.

Erythema /. Induration at injection site.

Mild fever in 1 - 5 %  of cases.


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