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Typhoid Vaccine
Also known as Vi Capsular Polysaccharide Typhoid Vaccine is a colourless and transparent injection in liquid form containing Vi capsular polysaccharide .
Composition is 0.5 ml that contains purified Vi capsular polysaccharide of Salmonella Typhu 25 mcg.
Indications:
Prevention of Typhoid fever in adults and children over 2 years of age.
Dosage :
A single intramuscular injection of Typbar 0.5 ml for adults and children over 2 years of age.
The protection lasts for upto 3 years.
Revaccination is needed once every 3 years to maintain protection.
Precautions:
Immunisation should be postponed in febrile subjects or in persons with acute infection.
Contraindications:
1. Hypersensitivity to any constituent of vaccine.
2. Pregnancy and lactation:
The risk during pregnancy is currently not exactly known.
Adverse Effects:
Mild pain at injection site.
Erythema /. Induration at injection site.
Mild fever in 1 - 5 % of cases.
Friday 8 June 2018
Sunday 3 June 2018
Pharmacology Made Simple : Ivabradine
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Ivabradine
Ivabradine is a medication which is used to reduce heart rate while fully preserving myocardial contra ction and relaxation,AV conduction and ventricular depolarisation as well as blood pressure.
It is a specific and selective inhibitor of if ion channel.After binding to this receptor,it reduces the slope for diastolic depolarisation and prolongs diastolic duration and thus decreasing the heat rate.
It is available in 5 mg and 7.5 mg tablets.
In Shift Trial : Systolic Heart Failure Treatment with the if Inhibitor Ivabradine Trial ,it was found that :
Ivabradine significantly reduced the relative risk of hospitalisation for worsening HF or CV death by 18%.
Ivabradine reduced the relative risk of hospitalisation for worsening Heart Failure by 26%.
Ivabradine reduces myocardial infarction in patients with Angina by 73%.
Other uses:
Ivabradine canbe successfully used in patients who are unable to tolerate maximum doses of beta blockers.
In Summary, Ivabradine can be used for:
Exclusive Heart Rate reductions
Reducing admission to hospital for MI and coronary revascularization.
Has no negative inotropic effect.
Is safe in patients with LVSD already on Beta Blocker
https://www.facebook.com/groups/405813783372378/
Ivabradine
Ivabradine is a medication which is used to reduce heart rate while fully preserving myocardial contra ction and relaxation,AV conduction and ventricular depolarisation as well as blood pressure.
It is a specific and selective inhibitor of if ion channel.After binding to this receptor,it reduces the slope for diastolic depolarisation and prolongs diastolic duration and thus decreasing the heat rate.
It is available in 5 mg and 7.5 mg tablets.
In Shift Trial : Systolic Heart Failure Treatment with the if Inhibitor Ivabradine Trial ,it was found that :
Ivabradine significantly reduced the relative risk of hospitalisation for worsening HF or CV death by 18%.
Ivabradine reduced the relative risk of hospitalisation for worsening Heart Failure by 26%.
Ivabradine reduces myocardial infarction in patients with Angina by 73%.
Other uses:
Ivabradine canbe successfully used in patients who are unable to tolerate maximum doses of beta blockers.
In Summary, Ivabradine can be used for:
Exclusive Heart Rate reductions
Reducing admission to hospital for MI and coronary revascularization.
Has no negative inotropic effect.
Is safe in patients with LVSD already on Beta Blocker
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