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Ivabradine
Ivabradine is a medication which is used to reduce heart rate while fully preserving myocardial contra ction and relaxation,AV conduction and ventricular depolarisation as well as blood pressure.
It is a specific and selective inhibitor of if ion channel.After binding to this receptor,it reduces the slope for diastolic depolarisation and prolongs diastolic duration and thus decreasing the heat rate.
It is available in 5 mg and 7.5 mg tablets.
In Shift Trial : Systolic Heart Failure Treatment with the if Inhibitor Ivabradine Trial ,it was found that :
Ivabradine significantly reduced the relative risk of hospitalisation for worsening HF or CV death by 18%.
Ivabradine reduced the relative risk of hospitalisation for worsening Heart Failure by 26%.
Ivabradine reduces myocardial infarction in patients with Angina by 73%.
Other uses:
Ivabradine canbe successfully used in patients who are unable to tolerate maximum doses of beta blockers.
In Summary, Ivabradine can be used for:
Exclusive Heart Rate reductions
Reducing admission to hospital for MI and coronary revascularization.
Has no negative inotropic effect.
Is safe in patients with LVSD already on Beta Blocker
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