Mechanism Of Action.
Rifaximin is a semi-synthetic derivative of rifampin and acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase blocking one of the steps in transcription.
This results in inhibition of bacterial protein synthesis and consequently inhibits the growth of bacteria.
Chemical Structure Of Rifaximin
Uses Of Rifaximin
Rifaximin Use in Hepatic Encephalopathy:
Other uses include treatment of: infectious diarrhea, small intestinal bacterial overgrowth, inflammatory bowel disease, and diverticular disease.
Rifaximin is effective in treating small intestinal bacterial overgrowth regardless of whether it is associated with irritable bowel syndrome or not.
BASIC STEPS IN MANAGEMENT OF HEPATIC ENCEPHALOPATHY
