Pharmacology Made Simple : Oral Hypoglycemics : Combination of Sitagliptin and Metformin

Combination of Sitagliptin and Metformin 50 mg / 500 mg :


A combination of Sitagliptin and Metformin 50 mg / 500 mg produces a greater reduction in HbA1c compared to Metformin alone.

A substantial number of patients : 49.2 % in the Sitagliptin =+ Metformin FDC group had an HbA1c < 7.0 % at week 18 as compared with 34.2% in Metformin monotherapy group.

31.8 % of patients with Sitagliptin - Metformin FDC Group achieved an HbA1c of < 6.5 % compared with 16.0 % in Metformin monotherapy group.

Treatment with Sitagliptin - Metformin FDC results in lower incidence of abdominal pain and diarrhea compared with Metformin monotherapy.

This combination improves glycemic control as well as beta cell function.

Sitagliptin - Metformin combination compared with Glipizide- Metformin combination led to better maintenance of Beta cell function after 2 years of treatment.

Disposition Index : an assessment of Beta cell responsiveness in relation to insulin sensitivity remained stable over 2 years with Sitagliptin - Metformin but declined from baseline with Glipizide - Metformin.