Pharmacology Made Simple : Antimicrobials : Cefexime

Salmonella and Shigella case significant mobidity and motality among children woldwide

Increased microbial resistance reslts in greater burden of disease.

Cefexime and Typhoid Fever:

Typhoid continues to pose a challenge even 100 years after its discovery.

Typhoid is a common cause of morbidity among young children worldwide including children below 2 years of age.

Cefexime exhibits low MIC 90 and high concentration against Typhoid fever.

MIC 90 against Salmonella typhi : 0.25 micrograms/ml2

Mean concentration in bile : 199.3 micrograms/ml3

Cefexime effectively treats MDR and NMDR Typhoid Fever with High Cure Rates.

Cefexime shows significant clinical efficacy of around 100 % with low rates of relapse.

Cefexime in Shigellosis Management :

Shigellosis is primarily a childhood disease in both developed and developing countries.

Over 163.2 million cases are reported in developing countries.

Cefexime exhibits low MIC 90 against Shigella species.

Cefexime is effective in treatmemt of suspected shigellosis in areas of high resistance to co-trimoxazole.