Sheehan"s syndrome :
This refers to hypopituitarism due to ischemic damage to the pituitary resulting from excessive haemorhage during delivery / parturition.
During pregnancy,the pituitary gland gets enlarged and metabolically more active and more susceptible to hypoxemia.
The blood vessels in pituitary are more suseptible to vasospasm due to excessive estrogen levels.
The clinical presentation depends on how much the pituitary gland has been damaged and the type of cells damaged.
For example damage to pituitary gonadotrophs and diminished secretion of gonadotrophs / LH may lead to Amenorrhoea.
Damage to lactotrophs will lead to reduced prolactin levels.
If the patient tries to breast feed her child in this case,most likel failure of lactation would be seen.
Damage to Corticotrophs will affect steroids metabolism and ACTH levels.
Hypothyroidism is also common
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