Endocrinology Made Simple : Causes Of Hypercalcemia

Causes Of Hypercalcemia

The causes of Hypercalcemia can be broadly divided into following two types :

1.Parathyroid Dependent

2.Parathyroid Independent

1.Parathyroid Dependent Hypercalcemia:

These may be.      

          

      a      Primary Hyperparathyroidsim

      b.      Tertiary Hyperparathyroidism

   

      c.       Lithium Induced Hypercalcemia

     

      d.      Familial Hypocalciuric Hypercalcemia

2 . Parathyroid Independent Hypercalcemia:

The causes of these are as follows:

       a.Malignancies

       b.Vitamin D Toxicity

       c.Granulomatous Disease

       d.Milk Alkali Syndrome

Malignancy Induced Hypercalcemia:

This occurs due to secretion of PTHrP and other haematological malignancies

It is important to measure serum PTH levels in order to classify if hypercalcemia is PTH Dependent or PTH 

Independent.