Systemic Treatment for Psoriasis
Should be initiated by experienced specialist dermatologists.
Indications:
1.Unstable inflamed psoriasis.
2.Widespread disease
3.Disease not responsive to topical or phototherapy.
4.Concomitant psoriatic arthropathy.
Types of Drugs used:
First Line include :
Methotrexate and acitretin.
Others commonly used
include:
Ciclosporin
Hydroxyurea
Azathioprine
Mycophenolate mofetil
Biological therapies
:
Infliximab
Etanercept
Efalizumab
Adalimumab
Methotrexate:
Is given as once weekly injection or tablet.
Is used for Rx of unstable erythrodermic pustular psoriasis
in acute setting and also maintenance therapy of
chronic plaque disease.
Side effects:
Hepatotoxicity / liver Damage.
Bonemarrow suppression / Myelosuppression.
Acitretin :
Is a Vitamin A derivative.
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