Clinical Genetics Made Simple : Developmental Disorders of Spinal Cord

Spina Bifida with Myelomeningocoele :

This condition occurs due to failure of posteriorly located vertebral arches to fuse posteriorly.

It can vary in severity from a completely asymptomatic minor abnormality to protrusion of the spinal

cord and its roots through an open skin defect with a  high risk of trauma or infection causing

paralysis.

Severe Scoliosis   :

This occurs due to failure of the development of  one of the paired primary ossification centres of the

body & it can produce very severe scoliosis.