Mechanism Of Action :
Cinnarizine inhibits contractions of vascular smooth muscle
cells by blocking L-type and T-type voltage gated calcium channels.
Cinnarizine has also been implicated in binding to dopamine
D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.
Uses / Indications :
Maintenance therapy for
Peripheral circulatory disorders : Raynaud"s
phenomenon,Acrocyanosis,intermittent claudication ,paresthesias,trophic and
varicose ulcers.
Cerebral circulatory disorders.
Maintenance therapy for symptoms of cerebrovascular origin (
dizziness,ear buzzing / tinnitus,vasccular headache,unsocialbility and
irritability disorders,loss of memory.
Prophylaxis of migraine.
Disorders of balance.
Cinnarizine is used for the control of vestibular disorders
such as vertigo, tinnitus, nausea and vomiting such as that seen in Meniere's
disease.
Cinnarizine is also effective in the control of motion
sickness.
Recommended Dosage :
25 mg tds in adults.
Side Effects :
Hypersomnia
Lethargy
Stomach discomfort
Vomiting
Dyspepsia
Fatigue
Hyperhidrosis
