Saturday 25 January 2020

Pharmacology Made Simple : Cinnarizine

Mechanism Of Action :

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels.


Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.

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Uses / Indications :

Maintenance therapy for  Peripheral circulatory disorders : Raynaud"s phenomenon,Acrocyanosis,intermittent claudication ,paresthesias,trophic and varicose ulcers.

Cerebral circulatory disorders.

Maintenance therapy for symptoms of cerebrovascular origin ( dizziness,ear buzzing / tinnitus,vasccular headache,unsocialbility and irritability disorders,loss of memory.

Prophylaxis of migraine.

Disorders of balance.

Cinnarizine is used for the control of vestibular disorders such as vertigo, tinnitus, nausea and vomiting such as that seen in Meniere's disease.

Cinnarizine is also effective in the control of motion sickness.

Recommended Dosage :
25 mg tds in adults.

Side Effects :

Hypersomnia

Lethargy

Stomach discomfort

Vomiting

Dyspepsia

Fatigue


Hyperhidrosis

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